A Prognostic DNA Methylation Signature for Stage I Non–Small-Cell Lung Cancer | Zendy

Juan Sandoval | Zendy; Jesús MéndezGonzález | Zendy; Ernest Nadal | Zendy; Guoan Chen | Zendy; F. Javier Carmona | Zendy; Sergi Sayols | Zendy; Sebastián Morán | Zendy; Holger Heyn | Zendy; Miguel Vizoso | Zendy; Antonio Gómez | Zendy; Montse SánchezCéspedes | Zendy; Yassen Assenov | Zendy; Fabian Müller | Zendy; Christoph Bock | Zendy; Miquel Tarón | Zendy; Josefina Móra | Zendy; Lucia Anna Muscarella | Zendy; Triantafillos Liloglou | Zendy; Michael Davies | Zendy; Marina Pollán | Zendy; María J. Pajares | Zendy; W. Torre | Zendy; Luis M. Montuenga | Zendy; Élisabeth Brambilla | Zendy; John K. Field | Zendy; Luca Roz | Zendy; Marco Lo Iacono | Zendy; Giorgio V. Scagliotti | Zendy; Rafael Rosell | Zendy; David G. Beer | Zendy; Manel Esteller | Zendy

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A Prognostic DNA Methylation Signature for Stage I Non–Small-Cell Lung Cancer

Author(s) -

Juan Sandoval,

Jesús MéndezGonzález,

Ernest Nadal,

Guoan Chen,

F. Javier Carmona,

Sergi Sayols,

Sebastián Morán,

Holger Heyn,

Miguel Vizoso,

Antonio Gómez,

Montse SánchezCéspedes,

Yassen Assenov,

Fabian Müller,

Christoph Bock,

Miquel Tarón,

Josefina Móra,

Lucia Anna Muscarella,

Triantafillos Liloglou,

Michael Davies,

Marina Pollán,

María J. Pajares,

W. Torre,

Luis M. Montuenga,

Élisabeth Brambilla,

John K. Field,

Luca Roz,

Marco Lo Iacono,

Giorgio V. Scagliotti,

Rafael Rosell,

David G. Beer,

Manel Esteller

Publication year - 2013

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2012.48.5516

Subject(s) - dna methylation , oncology , methylation , stage (stratigraphy) , medicine , cohort , lung cancer , cpg site , hazard ratio , cancer , proportional hazards model , cancer research , dna , biology , gene , gene expression , genetics , confidence interval , paleontology

Non-small-cell lung cancer (NSCLC) is a tumor in which only small improvements in clinical outcome have been achieved. The issue is critical for stage I patients for whom there are no available biomarkers that indicate which high-risk patients should receive adjuvant chemotherapy. We aimed to find DNA methylation markers that could be helpful in this regard.

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