Toward aNOTCH1/FBXW7/RAS/PTEN–Based Oncogenetic Risk Classification of Adult T-Cell Acute Lymphoblastic Leukemia: A Group for Research in Adult Acute Lymphoblastic Leukemia Study | Zendy

Amélie Trinquand | Zendy; Aline Schmidt | Zendy; Raouf Ben Abdelali | Zendy; Jérôme Lambert | Zendy; Kheïra Beldjord | Zendy; Étienne Lengliné | Zendy; Noémie de Gunzburg | Zendy; Dominique PayetBornet | Zendy; Ludovic Lhermitte | Zendy; Hossein Mossafa | Zendy; Véronique Lhéritier | Zendy; Jonathan Bond | Zendy; Françoise Huguet | Zendy; Agnès Buzyn | Zendy; T. Leguay | Zendy; JeanYves Cahn | Zendy; Xavier Thomas | Zendy; Yves Chalandon | Zendy; André Delannoy | Zendy; Caroline Bonmati | Zendy; Sébastien Maury | Zendy; Bertrand Nadel | Zendy; Elizabeth Macintyre | Zendy; Norbert Ifrah | Zendy; Hervé Dombret | Zendy; Vahid Asnafi | Zendy

Open Access

Toward aNOTCH1/FBXW7/RAS/PTEN–Based Oncogenetic Risk Classification of Adult T-Cell Acute Lymphoblastic Leukemia: A Group for Research in Adult Acute Lymphoblastic Leukemia Study

Author(s) -

Amélie Trinquand,

Aline Schmidt,

Raouf Ben Abdelali,

Jérôme Lambert,

Kheïra Beldjord,

Étienne Lengliné,

Noémie de Gunzburg,

Dominique PayetBornet,

Ludovic Lhermitte,

Hossein Mossafa,

Véronique Lhéritier,

Jonathan Bond,

Françoise Huguet,

Agnès Buzyn,

T. Leguay,

JeanYves Cahn,

Xavier Thomas,

Yves Chalandon,

André Delannoy,

Caroline Bonmati,

Sébastien Maury,

Bertrand Nadel,

Elizabeth Macintyre,

Norbert Ifrah,

Hervé Dombret,

Vahid Asnafi

Publication year - 2013

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2012.48.5292

Subject(s) - pten , medicine , hazard ratio , oncology , leukemia , lymphoblastic leukemia , cancer research , genetics , biology , confidence interval , pi3k/akt/mtor pathway , apoptosis

The Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL) recently reported a significantly better outcome in T-cell acute lymphoblastic leukemia (T-ALL) harboring NOTCH1 and/or FBXW7 (N/F) mutations compared with unmutated T-ALL. Despite this, one third of patients with N/F-mutated T-ALL experienced relapse.

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