Everolimus for Previously Treated Advanced Gastric Cancer: Results of the Randomized, Double-Blind, Phase III GRANITE-1 Study
Author(s) -
Atsushi Ohtsu,
Jaffer A. Ajani,
Yu-Xian Bai,
YungJue Bang,
Hyun Cheol Chung,
Hong-Ming Pan,
Tarek Sahmoud,
Lin Shen,
KunHuei Yeh,
Keisho Chìn,
Kei Muro,
Yeul Hong Kim,
David Ferry,
Niall C. Tebbutt,
SalahEddin AlBatran,
Heind Smith,
Chiara Costantini,
Syed Rizvi,
David Lebwohl,
Eric Van Cutsem
Publication year - 2013
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.2012.48.3552
Subject(s) - everolimus , medicine , ramucirumab , hazard ratio , clinical endpoint , adverse effect , cancer , placebo , phases of clinical research , gastroenterology , chemotherapy , surgery , oncology , clinical trial , confidence interval , pathology , alternative medicine
The oral mammalian target of rapamycin inhibitor everolimus demonstrated promising efficacy in a phase II study of pretreated advanced gastric cancer. This international, double-blind, phase III study compared everolimus efficacy and safety with that of best supportive care (BSC) in previously treated advanced gastric cancer.
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