Pooled Analysis of the Prognostic and Predictive Effects of KRAS Mutation Status and KRAS Mutation Subtype in Early-Stage Resected Non–Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy | Zendy

Frances A. Shepherd | Zendy; Caroline Domerg | Zendy; Pierre Hainaut | Zendy; Pasi A. Jänne | Zendy; JeanPierre Pig | Zendy; Stephen L. Graziano | Zendy; Jean-Yves Douillard | Zendy; E. Brambilla | Zendy; Thierry Le Chevalier | Zendy; Lesley Seymour | Zendy; Abderrahmane Bourredjem | Zendy; Gwénaël Le Teuff | Zendy; Robert Pirker | Zendy; Martin Filipits | Zendy; Rafael Rosell | Zendy; Robert A. Kratzke | Zendy; Bizhan Bandarchi | Zendy; Xiaoli Ma | Zendy; Marzia Capelletti | Zendy; JeanCharles Soria | Zendy; MingSound Tsao | Zendy

Open Access

Pooled Analysis of the Prognostic and Predictive Effects of KRAS Mutation Status and KRAS Mutation Subtype in Early-Stage Resected Non–Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy

Author(s) -

Frances A. Shepherd,

Caroline Domerg,

Pierre Hainaut,

Pasi A. Jänne,

JeanPierre Pig,

Stephen L. Graziano,

Jean-Yves Douillard,

E. Brambilla,

Thierry Le Chevalier,

Lesley Seymour,

Abderrahmane Bourredjem,

Gwénaël Le Teuff,

Robert Pirker,

Martin Filipits,

Rafael Rosell,

Robert A. Kratzke,

Bizhan Bandarchi,

Xiaoli Ma,

Marzia Capelletti,

JeanCharles Soria,

MingSound Tsao

Publication year - 2013

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2012.48.1390

Subject(s) - kras , medicine , hazard ratio , mutation , oncology , proportional hazards model , cancer , lung cancer , stage (stratigraphy) , gastroenterology , genetics , colorectal cancer , gene , biology , confidence interval , paleontology

We undertook this analysis of KRAS mutation in four trials of adjuvant chemotherapy (ACT) versus observation (OBS) to clarify the prognostic/predictive roles of KRAS in non-small-cell lung cancer (NSCLC).

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