Implementation of Universal Microsatellite Instability and Immunohistochemistry Screening for Diagnosing Lynch Syndrome in a Large Academic Medical Center | Zendy

Brandie Heald | Zendy; Thomas Plesec | Zendy; Xiuli Liu | Zendy; Rish K. Pai | Zendy; Deepa T. Patil | Zendy; Jessica Moline | Zendy; Richard R. Sharp | Zendy; Carol A. Burke | Zendy; Matthew F. Kalady | Zendy; James M. Church | Zendy; Charis Eng | Zendy

Open Access

Implementation of Universal Microsatellite Instability and Immunohistochemistry Screening for Diagnosing Lynch Syndrome in a Large Academic Medical Center

Author(s) -

Brandie Heald,

Thomas Plesec,

Xiuli Liu,

Rish K. Pai,

Deepa T. Patil,

Jessica Moline,

Richard R. Sharp,

Carol A. Burke,

Matthew F. Kalady,

James M. Church,

Charis Eng

Publication year - 2013

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2012.45.1674

Subject(s) - medicine , microsatellite instability , lynch syndrome , colorectal cancer , referral , immunohistochemistry , mlh1 , genetic counseling , oncology , general surgery , cancer , family medicine , dna mismatch repair , microsatellite , biochemistry , allele , chemistry , gene , genetics , biology

In 2009, the Evaluation of Genomic Applications in Practice and Prevention recommended that all colorectal cancers (CRCs) be screened for Lynch syndrome (LS) through microsatellite instability (MSI) or immunohistochemistry (IHC). No studies report how this process is implemented on a health system-wide basis.

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