Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy | Zendy

Dawn L. Hershman | Zendy; Joseph M. Unger | Zendy; Katherine D. Crew | Zendy; Lori M. Minasian | Zendy; Danielle Awad | Zendy; Carol M. Moinpour | Zendy; Lisa Hansen | Zendy; Danika L. Lew | Zendy; Heather Greenlee | Zendy; Louis Fehrenbacher | Zendy; James L. Wade | Zendy; SiuFun Wong | Zendy; Gabriel N. Hortobágyi | Zendy; Frank L. Meyskens | Zendy; Kathy S. Albain | Zendy

Open Access

Randomized Double-Blind Placebo-Controlled Trial of Acetyl-L-Carnitine for the Prevention of Taxane-Induced Neuropathy in Women Undergoing Adjuvant Breast Cancer Therapy

Author(s) -

Dawn L. Hershman,

Joseph M. Unger,

Katherine D. Crew,

Lori M. Minasian,

Danielle Awad,

Carol M. Moinpour,

Lisa Hansen,

Danika L. Lew,

Heather Greenlee,

Louis Fehrenbacher,

James L. Wade,

SiuFun Wong,

Gabriel N. Hortobágyi,

Frank L. Meyskens,

Kathy S. Albain

Publication year - 2013

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2012.44.8738

Subject(s) - medicine , taxane , placebo , chemotherapy induced peripheral neuropathy , breast cancer , randomized controlled trial , clinical endpoint , peripheral neuropathy , chemotherapy , cancer , endocrinology , alternative medicine , pathology , diabetes mellitus

Chemotherapy-induced peripheral neuropathy (CIPN) is common and leads to suboptimal treatment. Acetyl-L-carnitine (ALC) is a natural compound involved in neuronal protection. Studies have suggested ALC may be effective for the prevention and treatment of CIPN.

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