Molecular Profiling Improves Classification and Prognostication of Nodal Peripheral T-Cell Lymphomas: Results of a Phase III Diagnostic Accuracy Study | Zendy

Pier Paolo Piccaluga | Zendy; Fabio Fuligni | Zendy; Antonio De Leo | Zendy; Clara Bertuzzi | Zendy; Maura Rossi | Zendy; Francesco Bacci | Zendy; Elena Sabattini | Zendy; Claudio Agostinelli | Zendy; Anna Gazzola | Zendy; Maria Antonella Laginestra | Zendy; Claudia Mannu | Zendy; Maria Rosaria Sapienza | Zendy; Sylvia Hartmann | Zendy; Martin L. Hansmann | Zendy; Roberto Piva | Zendy; Javeed Iqbal | Zendy; John C. Chan | Zendy; Denis D. Weisenburger | Zendy; Julie M. Vose | Zendy; Monica Bellei | Zendy; Massimo Federico | Zendy; Giorgio Inghirami | Zendy; Pier Luigi Zinzani | Zendy; Stefano Pileri | Zendy

Open Access

Molecular Profiling Improves Classification and Prognostication of Nodal Peripheral T-Cell Lymphomas: Results of a Phase III Diagnostic Accuracy Study

Author(s) -

Pier Paolo Piccaluga,

Fabio Fuligni,

Antonio De Leo,

Clara Bertuzzi,

Maura Rossi,

Francesco Bacci,

Elena Sabattini,

Claudio Agostinelli,

Anna Gazzola,

Maria Antonella Laginestra,

Claudia Mannu,

Maria Rosaria Sapienza,

Sylvia Hartmann,

Martin L. Hansmann,

Roberto Piva,

Javeed Iqbal,

John C. Chan,

Denis D. Weisenburger,

Julie M. Vose,

Monica Bellei,

Massimo Federico,

Giorgio Inghirami,

Pier Luigi Zinzani,

Stefano Pileri

Publication year - 2013

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2012.42.5611

Subject(s) - anaplastic large cell lymphoma , medicine , lymphoma , not otherwise specified , peripheral t cell lymphoma , anaplastic lymphoma kinase , pathology , differential diagnosis , oncology , t cell , immunology , immune system , malignant pleural effusion , lung cancer

The differential diagnosis among the commonest peripheral T-cell lymphomas (PTCLs; ie, PTCL not otherwise specified [NOS], angioimmunoblastic T-cell lymphoma [AITL], and anaplastic large-cell lymphoma [ALCL]) is difficult, with the morphologic and phenotypic features largely overlapping. We performed a phase III diagnostic accuracy study to test the ability of gene expression profiles (GEPs; index test) to identify PTCL subtype.

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