Tissue Platinum Concentration and Tumor Response in Non–Small-Cell Lung Cancer | Zendy

Eric S. Kim | Zendy; J. Jack Lee | Zendy; Guangan He | Zendy; ChiWan Chow | Zendy; Junya Fujimoto | Zendy; Neda Kalhor | Zendy; Stephen G. Swisher | Zendy; Ignacio I. Wistuba | Zendy; David J. Stewart | Zendy; Zahid H. Siddik | Zendy

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Tissue Platinum Concentration and Tumor Response in Non–Small-Cell Lung Cancer

Author(s) -

Eric S. Kim,

J. Jack Lee,

Guangan He,

ChiWan Chow,

Junya Fujimoto,

Neda Kalhor,

Stephen G. Swisher,

Ignacio I. Wistuba,

David J. Stewart,

Zahid H. Siddik

Publication year - 2012

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2011.40.8120

Subject(s) - carboplatin , platinum , cisplatin , medicine , lung cancer , chemotherapy , oncology , pathology , biology , biochemistry , catalysis

Platinum resistance is a major limitation in the treatment of advanced non-small-cell lung cancer (NSCLC). Reduced intracellular drug accumulation is one of the most consistently identified features of platinum-resistant cell lines, but clinical data are limited. We assessed the effects of tissue platinum concentrations on response and survival in NSCLC.

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