Association Between Circulating Tumor Cells and Prognosis in Patients With Stage III Melanoma With Sentinel Lymph Node Metastasis in a Phase III International Multicenter Trial | Zendy

Sojun Hoshimoto | Zendy; Tatsushi Shingai | Zendy; Donald L. Morton | Zendy; Christine Kuo | Zendy; Mark B. Faries | Zendy; Kelly K. Chong | Zendy; David Elashoff | Zendy; Hong Wang | Zendy; Robert M. Elashoff | Zendy; Dave S.�B. Hoon | Zendy

Open Access

Association Between Circulating Tumor Cells and Prognosis in Patients With Stage III Melanoma With Sentinel Lymph Node Metastasis in a Phase III International Multicenter Trial

Author(s) -

Sojun Hoshimoto,

Tatsushi Shingai,

Donald L. Morton,

Christine Kuo,

Mark B. Faries,

Kelly K. Chong,

David Elashoff,

Hong Wang,

Robert M. Elashoff,

Dave S.�B. Hoon

Publication year - 2012

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2011.40.0887

Subject(s) - medicine , melanoma , hazard ratio , oncology , biomarker , circulating tumor cell , lymphadenectomy , adjuvant , lymph node , sentinel lymph node , metastasis , cancer , confidence interval , cancer research , breast cancer , biochemistry , chemistry

The outcomes of patients with melanoma who have sentinel lymph node (SLN) metastases can be highly variable, which has precluded establishment of consensus regarding treatment of the group. The detection of high-risk patients from this clinical setting may be helpful for determination of both prognosis and management. We report the utility of multimarker reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) detection of circulating tumor cells (CTCs) in patients with melanoma diagnosed with SLN metastases in a phase III, international, multicenter clinical trial.

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