Nonadherence to Oral Mercaptopurine and Risk of Relapse in Hispanic and Non-Hispanic White Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group | Zendy

Smita Bhatia | Zendy; Wendy Landier | Zendy; Muyun Shangguan | Zendy; Lindsey Hageman | Zendy; Alexandra Schaible | Zendy; Andrea R. Carter | Zendy; Cara Hanby | Zendy; Wendy M. Leisenring | Zendy; Yutaka Yasui | Zendy; Nancy M. Kornegay | Zendy; Leo Mascarenhas | Zendy; A. Kim Ritchey | Zendy; Jacqueline Casillas | Zendy; David S. Dickens | Zendy; Jane L. Meza | Zendy; William L. Carroll | Zendy; Mary V. Relling | Zendy; F. Lennie Wong | Zendy

Open Access

Nonadherence to Oral Mercaptopurine and Risk of Relapse in Hispanic and Non-Hispanic White Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group

Author(s) -

Smita Bhatia,

Wendy Landier,

Muyun Shangguan,

Lindsey Hageman,

Alexandra Schaible,

Andrea R. Carter,

Cara Hanby,

Wendy M. Leisenring,

Yutaka Yasui,

Nancy M. Kornegay,

Leo Mascarenhas,

A. Kim Ritchey,

Jacqueline Casillas,

David S. Dickens,

Jane L. Meza,

William L. Carroll,

Mary V. Relling,

F. Lennie Wong

Publication year - 2012

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2011.38.9924

Subject(s) - medicine , mercaptopurine , hazard ratio , lymphoblastic leukemia , confidence interval , cumulative incidence , incidence (geometry) , gastroenterology , pediatrics , leukemia , cohort , physics , optics

Systemic exposure to mercaptopurine (MP) is critical for durable remissions in children with acute lymphoblastic leukemia (ALL). Nonadherence to oral MP could increase relapse risk and also contribute to inferior outcome in Hispanics. This study identified determinants of adherence and described impact of adherence on relapse, both overall and by ethnicity.

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