RAS Mutations Are Associated With the Development of Cutaneous Squamous Cell Tumors in Patients Treated With RAF Inhibitors | Zendy

Patrick A. Oberholzer | Zendy; Damien Kee | Zendy; Piotr Dziunycz | Zendy; Antje Sucker | Zendy; Nyam Kamsu-Kom | Zendy; Robert T. Jones | Zendy; Christine Roden | Zendy; Clinton J. Chalk | Zendy; Kristin Ardlie | Zendy; Emanuele Palescandolo | Zendy; Adriano Piris | Zendy; Laura E. MacConaill | Zendy; Caroline Robert | Zendy; Günther F.L. Hofbauer | Zendy; Grant A. McArthur | Zendy; Dirk Schadendorf | Zendy; Levi A. Garraway | Zendy

Open Access

RAS Mutations Are Associated With the Development of Cutaneous Squamous Cell Tumors in Patients Treated With RAF Inhibitors

Author(s) -

Patrick A. Oberholzer,

Damien Kee,

Piotr Dziunycz,

Antje Sucker,

Nyam Kamsu-Kom,

Robert T. Jones,

Christine Roden,

Clinton J. Chalk,

Kristin Ardlie,

Emanuele Palescandolo,

Adriano Piris,

Laura E. MacConaill,

Caroline Robert,

Günther F.L. Hofbauer,

Grant A. McArthur,

Dirk Schadendorf,

Levi A. Garraway

Publication year - 2011

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2011.36.7680

Subject(s) - hras , medicine , kras , cancer research , cdkn2a , neuroblastoma ras viral oncogene homolog , immunosuppression , mutation , cancer , vemurafenib , melanoma , gene , colorectal cancer , biology , metastatic melanoma , biochemistry

RAF inhibitors are effective against melanomas with BRAF V600E mutations but may induce keratoacanthomas (KAs) and cutaneous squamous cell carcinomas (cSCCs). The potential of these agents to promote secondary malignancies is concerning. We analyzed cSCC and KA lesions for genetic mutations in an attempt to identify an underlying mechanism for their formation.

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