Use of Zidovudine and Interferon Alfa With Chemotherapy Improves Survival in Both Acute and Lymphoma Subtypes of Adult T-Cell Leukemia/Lymphoma | Zendy

Andrew Hodson | Zendy; Siobhan Crichton | Zendy; Silvia Montoto | Zendy; Naheed Mir | Zendy; Estella Matutes | Zendy; Kate Cwynarski | Zendy; Thurai Kumaran | Zendy; Kirit M. Ardeshna | Zendy; Antonio Pagliuca | Zendy; Graham P. Taylor | Zendy; Paul Fields | Zendy

Open Access

Use of Zidovudine and Interferon Alfa With Chemotherapy Improves Survival in Both Acute and Lymphoma Subtypes of Adult T-Cell Leukemia/Lymphoma

Author(s) -

Andrew Hodson,

Siobhan Crichton,

Silvia Montoto,

Naheed Mir,

Estella Matutes,

Kate Cwynarski,

Thurai Kumaran,

Kirit M. Ardeshna,

Antonio Pagliuca,

Graham P. Taylor,

Paul Fields

Publication year - 2011

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2011.35.5578

Subject(s) - medicine , lymphoma , chemotherapy , zidovudine , oncology , acute leukemia , gastroenterology , leukemia , hazard ratio , adult t cell leukemia/lymphoma , immunology , t cell leukemia , viral disease , virus , confidence interval

Adult T-cell leukemia/lymphoma (ATLL) is a mature (post-thymic) T-cell lymphoma associated with human T-lymphotropic virus type 1 infection. Survival in aggressive subtypes remains poor, and treatment resistance is frequent. Use of zidovudine (ZDV) and interferon alfa (IFN-α) has been associated with improved response rates in small studies and prolonged overall survival in leukemic ATLL subtypes in a recent meta-analysis.

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