Adjuvant Tamoxifen Reduces Subsequent Breast Cancer in Women With Estrogen Receptor–Positive Ductal Carcinoma in Situ: A Study Based on NSABP Protocol B-24
Author(s) -
D. Craig Allred,
Stewart Anderson,
Soonmyung Paik,
D. Lawrence Wickerham,
Irıs D. Nagtegaal,
Sandra M. Swain,
Elefetherios P. Mamounas,
Thomas B. Julian,
Charles E. Geyer,
Joseph P. Costantino,
Stephanie R. Land,
Norman Wolmark
Publication year - 2012
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.2010.34.0141
Subject(s) - medicine , tamoxifen , breast cancer , estrogen receptor , lumpectomy , ductal carcinoma , oncology , progesterone receptor , population , hazard ratio , cancer , immunohistochemistry , gynecology , urology , mastectomy , confidence interval , environmental health
The NSABP (National Surgical Adjuvant Breast and Bowel Project) B-24 study demonstrated significant benefit with adjuvant tamoxifen in patients with ductal carcinoma in situ (DCIS) after lumpectomy and radiation. Patients were enrolled without knowledge of hormone receptor status. The current study retrospectively evaluated the relationship between receptors and response to tamoxifen.
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