Standardization of Estrogen Receptor Measurement in Breast Cancer Suggests False-Negative Results Are a Function of Threshold Intensity Rather Than Percentage of Positive Cells | Zendy

Allison W. Welsh | Zendy; C. Moeder | Zendy; Sudha Kumar | Zendy; Peter Gershkovich | Zendy; Elaine T. Alarid | Zendy; Malini Harigopal | Zendy; Bruce G. Haffty | Zendy; David L. Rimm | Zendy

Open Access

Standardization of Estrogen Receptor Measurement in Breast Cancer Suggests False-Negative Results Are a Function of Threshold Intensity Rather Than Percentage of Positive Cells

Author(s) -

Allison W. Welsh,

C. Moeder,

Sudha Kumar,

Peter Gershkovich,

Elaine T. Alarid,

Malini Harigopal,

Bruce G. Haffty,

David L. Rimm

Publication year - 2011

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2010.32.9706

Subject(s) - medicine , breast cancer , immunohistochemistry , estrogen receptor , tissue microarray , oncology , cancer , pathology

Recent misclassification (false negative) incidents have raised awareness concerning limitations of immunohistochemistry (IHC) in assessment of estrogen receptor (ER) in breast cancer. Here we define a new method for standardization of ER measurement and then examine both change in percentage and threshold of intensity (immunoreactivity) to assess sources for test discordance.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research

Address

John Eccles House
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom

About

About Careers Publisher Partners Contact Us Our institutional solutions Get Organisational Trial or Quote

Learn

FAQs Blog Terms of Use Privacy Policy

Download the Zendy App

Discover

Explore

Home ZAIA Blog