Transcriptome-Wide Studies of Merkel Cell Carcinoma and Validation of Intratumoral CD8+ Lymphocyte Invasion As an Independent Predictor of Survival
Author(s) -
Kelly G. Paulson,
Jayasri G. Iyer,
Andrew Tegeder,
Renee Thibodeau,
Janell M. Schelter,
S Koba,
David Schrama,
William Simonson,
Bianca D. Lemos,
David R. Byrd,
David M. Koelle,
Denise A. Galloway,
J. Helen Leonard,
Margaret M. Madeleine,
Zsolt B. Argényi,
Mary L. Disis,
Juergen C. Becker,
Michele A. Cleary,
Paul Nghiem
Publication year - 2011
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.2010.30.6308
Subject(s) - merkel cell carcinoma , transcriptome , medicine , cd8 , lymphocyte , cancer research , tumor infiltrating lymphocytes , merkel cell , oncology , carcinoma , overall survival , pathology , immunology , immune system , biology , gene expression , gene , biochemistry
Merkel cell carcinoma (MCC) is a polyomavirus-associated skin cancer that is frequently lethal and lacks established prognostic biomarkers. This study sought to identify biomarkers that improve prognostic accuracy and provide insight into MCC biology.
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