Phase III Trial Comparing Protracted Intravenous Fluorouracil Infusion Alone or With Yttrium-90 Resin Microspheres Radioembolization for Liver-Limited Metastatic Colorectal Cancer Refractory to Standard Chemotherapy | Zendy

Alain Hendlisz | Zendy; Marc Van den Eynde | Zendy; Marc Peeters | Zendy; Geert Maleux | Zendy; Bieke Lambert | Zendy; Jaarke Vannoote | Zendy; Katrien De Keukeleire | Zendy; Chris Verslype | Zendy; Luc Defreyne | Zendy; Eric Van Cutsem | Zendy; Philippe Delatte | Zendy; Thierry Delaunoit | Zendy; Nicola Personeni | Zendy; Marianne Paesmans | Zendy; JeanLuc Van Laethem | Zendy; Patrick Flamen | Zendy

Open Access

Phase III Trial Comparing Protracted Intravenous Fluorouracil Infusion Alone or With Yttrium-90 Resin Microspheres Radioembolization for Liver-Limited Metastatic Colorectal Cancer Refractory to Standard Chemotherapy

Author(s) -

Alain Hendlisz,

Marc Van den Eynde,

Marc Peeters,

Geert Maleux,

Bieke Lambert,

Jaarke Vannoote,

Katrien De Keukeleire,

Chris Verslype,

Luc Defreyne,

Eric Van Cutsem,

Philippe Delatte,

Thierry Delaunoit,

Nicola Personeni,

Marianne Paesmans,

JeanLuc Van Laethem,

Patrick Flamen

Publication year - 2010

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2010.28.5643

Subject(s) - medicine , refractory (planetary science) , fluorouracil , colorectal cancer , microsphere , chemotherapy , surgery , oncology , cancer , physics , astrobiology , chemical engineering , engineering

Liver dissemination is a major cause of mortality among patients with advanced colorectal cancer. Hepatic intra-arterial injection of the beta-emitting isotope yttrium-90 ((90)Y) bound to resin microspheres (radioembolization) delivers therapeutic radiation doses to liver metastases with minimal damage to adjacent tissues.

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