Open AccessReducing Unnecessary Biopsy During Prostate Cancer Screening Using a Four-Kallikrein Panel: An Independent Replication
Author(s) -
Andrew J. Vickers,
Angel M. Cronin,
Monique J. Roobol,
Caroline Savage,
Mari Peltola,
Kim Pettersson,
Peter T. Scardino,
Fritz H. Schröder,
Hans Lilja
Publication year - 2010
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.2009.24.1968
Subject(s) - medicine , prostate cancer , biopsy , rectal examination , prostate biopsy , cancer , cohort , prostate , prostate specific antigen , population , oncology , urology , environmental health
We previously reported that a panel of four kallikrein forms in blood-total, free, and intact prostate-specific antigen (PSA) and kallikrein-related peptidase 2 (hK2)-can reduce unnecessary biopsy in previously unscreened men with elevated total PSA. We aimed to replicate our findings in a large, independent, representative, population-based cohort.
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