Open AccessEffects of Chemotherapy in AIDS-Associated Non-Hodgkin's Lymphoma on Kaposi's Sarcoma Herpesvirus DNA in Blood
Author(s) -
Lan Lin,
Jeannette Y. Lee,
Lawrence D. Kaplan,
Bruce J. Dezube,
Ariela Noy,
Susan E. Krown,
Alexandra M. Levine,
Yanxing Yu,
Gary S. Hayward,
Richard F. Ambinder
Publication year - 2009
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.2008.20.1707
Subject(s) - peripheral blood mononuclear cell , viremia , lymphoma , virology , medicine , primary effusion lymphoma , immunology , non hodgkin's lymphoma , virus , cancer research , biology , in vitro , biochemistry
To determine the relative frequency with which Kaposi's sarcoma-associated herpesvirus/HHV-8 (KSHV) DNA is detected in peripheral-blood mononuclear cells (PBMCs) and in plasma of patients with AIDS-KS and AIDS-associated non-Hodgkin's lymphoma (NHL; AIDS-NHL); to determine whether the presence of viral DNA in plasma reflects lysis of tumor cells or reflects the presence of viremia (ie, virion-encapsidated DNA); and to determine the effect of lymphoma therapy on KSHV DNA.
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