Significant Associations of Mismatch Repair Gene Polymorphisms With Clinical Outcome of Pancreatic Cancer | Zendy

Xiaoqun Dong | Zendy; Li Jiao | Zendy; Yanan Li | Zendy; Douglas B. Evans | Zendy; Huamin Wang | Zendy; Kenneth R. Hess | Zendy; James L. Abbruzzese | Zendy; Donghui Li | Zendy

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Significant Associations of Mismatch Repair Gene Polymorphisms With Clinical Outcome of Pancreatic Cancer

Author(s) -

Xiaoqun Dong,

Li Jiao,

Yanan Li,

Douglas B. Evans,

Huamin Wang,

Kenneth R. Hess,

James L. Abbruzzese,

Donghui Li

Publication year - 2009

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2008.20.1111

Subject(s) - medicine , gemcitabine , single nucleotide polymorphism , genotype , pancreatic cancer , oncology , proportional hazards model , chemoradiotherapy , adenocarcinoma , dna mismatch repair , gastroenterology , cancer , gene , biology , genetics , colorectal cancer

DNA mismatch repair (MMR) is critical in maintaining genomic stability and may modulate the cellular response to gemcitabine. We hypothesized that genetic variations in MMR may affect the clinical outcome of patients with pancreatic cancer.

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