Open AccessDurable Long-Term Remission With Chemotherapy Alone for Stage II to IV Laryngeal Cancer
Author(s) -
F. Christopher Holsinger,
Merrill S. Kies,
Eduardo M. Diaz,
Ann M. Gillenwater,
Jan S. Lewin,
Lawrence E. Ginsberg,
Bonnie S. Glisson,
Adam S. Garden,
Nebil Ark,
Heather Lin,
J. Jack Lee,
Adel K. ElNaggar,
Waun Ki Hong,
Dong M. Shin,
Fadlo R. Khuri
Publication year - 2009
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.2008.17.6396
Subject(s) - medicine , chemotherapy , surgery , radiation therapy , cancer , stage (stratigraphy) , cisplatin , prospective cohort study , progressive disease , paleontology , biology
For patients with stage II to IV laryngeal cancer, radiation therapy (RT) either alone or with concurrent chemotherapy provides the highest rate of organ preservation but can be associated with functional impairment. Thus, we studied the use of induction chemotherapy with or without conservation laryngeal surgery (CLS). Our objectives were to study the sensitivity of laryngeal cancer to platinum-based chemotherapy alone and to highlight the efficacy of CLS in this setting.
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