Immunohistochemical Prognostic Markers in Diffuse Large B-Cell Lymphoma: Validation of Tissue Microarray As a Prerequisite for Broad Clinical Applications—A Study From the Lunenburg Lymphoma Biomarker Consortium | Zendy

Daphne de Jong | Zendy; Andreas Rosenwald | Zendy; Mukesh Chhanabhai | Zendy; Philippe Gaulard | Zendy; Wolfram Klapper | Zendy; Abigail Lee | Zendy; Birgitta Sander | Zendy; Christoph Thorns | Zendy; Elı́as Campo | Zendy; Thierry Jo Molina | Zendy; A. J. Norton | Zendy; Anton Hagenbeek | Zendy; Sandra J. Horning | Zendy; Andrew Lister | Zendy; John Raemaekers | Zendy; Randy D. Gascoyne | Zendy; Gilles Salles | Zendy; Edie Weller | Zendy

Open Access

Immunohistochemical Prognostic Markers in Diffuse Large B-Cell Lymphoma: Validation of Tissue Microarray As a Prerequisite for Broad Clinical Applications—A Study From the Lunenburg Lymphoma Biomarker Consortium

Author(s) -

Daphne de Jong,

Andreas Rosenwald,

Mukesh Chhanabhai,

Philippe Gaulard,

Wolfram Klapper,

Abigail Lee,

Birgitta Sander,

Christoph Thorns,

Elı́as Campo,

Thierry Jo Molina,

A. J. Norton,

Anton Hagenbeek,

Sandra J. Horning,

Andrew Lister,

John Raemaekers,

Randy D. Gascoyne,

Gilles Salles,

Edie Weller

Publication year - 2007

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.2006.09.4490

Subject(s) - tissue microarray , immunohistochemistry , medicine , concordance , lymphoma , biomarker , pathology , diffuse large b cell lymphoma , oncology , cd20 , follicular lymphoma , biology , biochemistry

The results of immunohistochemical class prediction and prognostic stratification of diffuse large B-cell lymphoma (DLBCL) have been remarkably various thus far. Apart from biologic variations, this may be caused by differences in laboratory techniques, scoring definitions, and inter- and intraobserver variations. In this study, an international collaboration of clinical lymphoma research groups from Europe, United States, and Canada concentrated on validation and standardization of immunohistochemistry of the currently potentially interesting prognostic markers in DLBCL.

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