Open AccessEffect of Chest X-Rays on the Risk of Breast Cancer Among BRCA1/2 Mutation Carriers in the International BRCA1/2 Carrier Cohort Study: A Report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators’ Group
Author(s) -
Nadine Andrieu,
Douglas F. Easton,
Jenny ChangClaude,
Matti A. Rookus,
Richard M. Brohet,
Elisabeth Cardis,
Antonis C. Antoniou,
Teresa Wagner,
Jacques Simard,
D. Gareth Evans,
Susan Peock,
Jean-Pierre Fricker,
Catherine Noguès,
Laura van’t Veer,
Flora E. van Leeuwen,
David E. Goldgar
Publication year - 2006
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.2005.03.3126
Subject(s) - medicine , breast cancer , cohort , population , ionizing radiation , germline mutation , cancer , proportional hazards model , oncology , risk factor , hazard ratio , cohort study , gynecology , mutation , genetics , irradiation , environmental health , gene , confidence interval , physics , biology , nuclear physics
Women who carry germline mutations in the BRCA1 and BRCA2 genes are at greatly increased risk of breast cancer (BC). Numerous studies have shown that moderate to high doses of ionizing radiation are a risk factor for BC. Because of the role of the BRCA proteins in DNA repair, we hypothesized that BRCA carriers might be more sensitive to ionizing radiation than women in the general population.
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