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Mitoxantrone, Etoposide, and Cytarabine With or Without Valspodar in Patients With Relapsed or Refractory Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome: A Phase III Trial (E2995)
Author(s) -
Peter L. Greenberg,
Sandra J. Lee,
Ranjana H. Advani,
Martin S. Tallman,
Branimir I. Šikić,
Louis Letendre,
Kathleen Dugan,
Bert L. Lum,
David L. Chin,
Gordon W. Dewald,
Elisabeth Paietta,
John M. Bennett,
Jacob M. Rowe
Publication year - 2004
Publication title -
journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.482
H-Index - 548
eISSN - 1527-7755
pISSN - 0732-183X
DOI - 10.1200/jco.2004.07.048
Subject(s) - medicine , mitoxantrone , cytarabine , etoposide , myeloid leukemia , refractory (planetary science) , myelodysplastic syndromes , oncology , chemotherapy , bone marrow , physics , astrobiology
To determine whether adding the multidrug resistance gene-1 (MDR-1) modulator valspodar (PSC 833; Novartis Pharmaceuticals, Hanover, NJ) to chemotherapy provided clinical benefit to patients with poor-risk acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS).

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