Adjuvant Whole-Brain Radiation Therapy Compared With Observation After Local Treatment of Melanoma Brain Metastases: A Multicenter, Randomized Phase III Trial | Zendy

Angela Hong | Zendy; Gerald Fogarty | Zendy; Kari Dolven-Jacobsen | Zendy; Bryan Burmeister | Zendy; Serigne Lo | Zendy; Lauren E. Haydu | Zendy; Janette Vardy | Zendy; Anna K. Nowak | Zendy; Haryana M. Dhillon | Zendy; Tasnia Ahmed | Zendy; Brindha Shivalingam | Zendy; Georgina V. Long | Zendy; Alexander M. Menzies | Zendy; George Hruby | Zendy; Katharine J. Drummond | Zendy; Catherine Mandel | Zendy; Mark R. Middleton | Zendy; Claudius H. Reisse | Zendy; Elizabeth Paton | Zendy; Victoria Steel | Zendy; Narelle Williams | Zendy; Richard A. Scolyer | Zendy; Rachael L. Morton | Zendy; John F. Thompson | Zendy

Open Access

Adjuvant Whole-Brain Radiation Therapy Compared With Observation After Local Treatment of Melanoma Brain Metastases: A Multicenter, Randomized Phase III Trial

Author(s) -

Angela Hong,

Gerald Fogarty,

Kari Dolven-Jacobsen,

Bryan Burmeister,

Serigne Lo,

Lauren E. Haydu,

Janette Vardy,

Anna K. Nowak,

Haryana M. Dhillon,

Tasnia Ahmed,

Brindha Shivalingam,

Georgina V. Long,

Alexander M. Menzies,

George Hruby,

Katharine J. Drummond,

Catherine Mandel,

Mark R. Middleton,

Claudius H. Reisse,

Elizabeth Paton,

Victoria Steel,

Narelle Williams,

Richard A. Scolyer,

Rachael L. Morton,

John F. Thompson

Publication year - 2019

Publication title -

journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.482

H-Index - 548

eISSN - 1527-7755

pISSN - 0732-183X

DOI - 10.1200/jco.19.01414

Subject(s) - medicine , radiosurgery , radiation therapy , randomized controlled trial , clinical endpoint , odds ratio , melanoma , brain metastasis , adjuvant , surgery , oncology , cancer , metastasis , cancer research

The brain is a common site of metastasis for patients with high-risk melanoma. Although surgery or stereotactic radiosurgery are highly effective local treatments for a small number of metastases, there is a high risk of developing additional brain metastases. The role of adjuvant whole-brain radiotherapy (WBRT) in reducing new metastases is controversial, with a lack of high-level evidence specifically for melanoma.

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