English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

In this work, we develop and analyze mathematical models for thecoupled within-host and between-host dynamics caricaturing the evolutionof HIV/AIDS. The host population is divided into susceptible, the infectedwithout receiving treatment and the infected receiving ART treatment in accordancewith China’s Four-Free-One-Care Policy. The within-host model is a typicalODE model adopted from literatures. The between-host model incorporatesage-since-infection described by a system of integrodifferential equations. Thetwo models are coupled via the viral load and number of CD4+ T cells ofwithin the hosts. For the between-host model with an arbitrarily selectedHIV infected individual, we focus on the analyses of the basic reproductionnumber R0 and the stabilities of equilibria. Through simulations we also findthat the within-host dynamics does influence the between-host dynamics, andthe nesting of within-host and between-host play a very important role in theHIV/AIDS evolution.

THE COUPLED WITHIN-AND BETWEEN-HOST DYNAMICS IN THE EVOLUTION OF HIV/AIDS IN CHINA