Use of the Highly Biocompatible Au Nanocages@PEG Nanoparticles as a New Contrast Agent for In Vivo Computed Tomography Scan Imaging | Zendy

Yan Gao | Zendy; Jian Kang | Zendy; Zhen Lei | Zendy; Yankun Li | Zendy; Xifan Mei | Zendy; Guannan Wang | Zendy

Open Access

Use of the Highly Biocompatible Au Nanocages@PEG Nanoparticles as a New Contrast Agent for In Vivo Computed Tomography Scan Imaging

Author(s) -

Yan Gao,

Jian Kang,

Zhen Lei,

Yankun Li,

Xifan Mei,

Guannan Wang

Publication year - 2020

Publication title -

nanoscale research letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.87

H-Index - 107

eISSN - 1931-7573

pISSN - 1556-276X

DOI - 10.1186/s11671-020-3286-2

Subject(s) - nanocages , in vivo , materials science , nanoparticle , nanochemistry , biocompatible material , biomedical engineering , preclinical imaging , nanotechnology , contrast (vision) , chemistry , medicine , computer science , organic chemistry , microbiology and biotechnology , artificial intelligence , biology , catalysis

In recent years, contrast agents have been widely used in imaging technology to improve quality. Nanoparticles have better in vivo detection capability than conventional molecular scale contrast agents. In this study, a new type of Au nanocages@PEG nanoparticles (AuNC@PEGs) with a strong X-ray absorption coefficient was synthesized as a contrast agent for computed tomography (CT) scan imaging. Results showed that AuNC@PEGs had good aqueous dispensation, low cytotoxicity, and strong X-ray absorption ability. Furthermore, in vivo studies have shown that the synthesized AuNC@PEGs have an evident contrast enhancement, long circulation time in the blood, and negligible toxicity in vivo. Therefore, the synthesized functionalized AuNC@PEGs in this study have great potential for clinical application in CT scan imaging.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research