From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development | Zendy

Minke van Tuyl | Zendy; Martin Post | Zendy

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From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development

Author(s) -

Minke van Tuyl,

Martin Post

Publication year - 2000

Publication title -

respiratory research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.846

H-Index - 104

eISSN - 1465-993X

pISSN - 1465-9921

DOI - 10.1186/rr9

Subject(s) - hedgehog signaling pathway , hedgehog , sonic hedgehog , smoothened , biology , microbiology and biotechnology , morphogenesis , signalling , signal transduction , genetics , gene

The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system. Hedgehog signalling in the lung involves Gli transcription proteins, but their potential downstream target genes have yet to be identified. Bmp4 and Fgf10 have been shown to regulate lung branching morphogenesis but seem not to be targets of hedgehog signalling.

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