How close is the bench to the bedside? Metabolic profiling in cancer research | Zendy

Que N. Van | Zendy; Timothy D. Veenstra | Zendy

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How close is the bench to the bedside? Metabolic profiling in cancer research

Author(s) -

Que N. Van,

Timothy D. Veenstra

Publication year - 2009

Publication title -

genome medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.564

H-Index - 89

ISSN - 1756-994X

DOI - 10.1186/gm5

Subject(s) - metabolomics , computational biology , profiling (computer programming) , medicine , bioinformatics , bench to bedside , proteomics , systems biology , biomarker discovery , medical physics , biology , computer science , biochemistry , gene , operating system

Metabolic profiling using mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR) is integral to the rapidly expanding field of metabolomics, which is making progress in toxicology, plant science and various diseases, including cancer. In the area of oncology and metabolic phenotyping, researchers have probed the known changes in malignant cellular pathways using new experimental techniques to gain more insights, and others are exploiting these same cellular pathways for therapeutic drug targets and for novel cancer biomarkers, with the ultimate goal of translation to the clinic. Here, we discuss the challenges and opportunities in metabolic phenotyping for discovering novel cancer biomarkers, and we assess the clinical applicability of MS and NMR.

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