Open AccessPredictors of successful treatment in patients receiving intra‐articular injections of hylan G‐F 20 or saline for painful first MTPJ OA
Author(s) -
Munteanu Shan,
Zammit Gerard V,
Menz Hylton B
Publication year - 2011
Publication title -
journal of foot and ankle research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.763
H-Index - 39
ISSN - 1757-1146
DOI - 10.1186/1757-1146-4-s1-p42
Subject(s) - medicine , logistic regression , physical therapy , range of motion , orthopedic surgery , univariate analysis , rehabilitation , intra articular , surgery , multivariate analysis , osteoarthritis , pathology , alternative medicine
Methods One hundred and fifty one participants with first MTPJ OA received an intra-articular injection of 1ml hylan GF 20 or saline. Potential predictors included intervention group, demographics, height weight, BMI, symptom duration and severity, the Foot Health Status Questionnaire (FHSQ), first MTPJ dorsiflexion range of motion and radiographic OA severity (osteophytes and joint space narrowing as individual features in either the dorsal and lateral view, or as a combination, where scores of 2 for any feature in any view was considered ‘definite’ OA). The primary measure was a 15-point change in symptoms scale (range -7‘a very great deal worse’ to +7 – ‘a very great deal better’) at 12-weeks, dichotomised with scores of 3 defined as treatment success. Predictor variables were initially analysed with univariate analyses. Significant variables were than entered into a backward stepwise multivariate logistic regression.