Open AccessCalf cramp in children with Charcot‐Marie‐Tooth disease: searching for therapeutic targets
Author(s) -
Hawke Fiona,
Ryan Monique,
Ouvrier Robert,
Burns Joshua
Publication year - 2011
Publication title -
journal of foot and ankle research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.763
H-Index - 39
ISSN - 1757-1146
DOI - 10.1186/1757-1146-4-s1-o18
Subject(s) - medicine , tooth disease , disease , orthopedic surgery , physical medicine and rehabilitation , bioinformatics , physical therapy , surgery , biology
Background Leg muscle cramps have been identified as the strongest independent predictor of worse quality of life in Australian children with Charcot-Marie-Tooth disease Type 1A (CMT1A). There is no accepted treatment for cramp in children with CMT and the cause of cramp is not well understood. Potential therapeutic targets should be carefully identified to direct clinical trials of interventions.