Open AccessThe endothelin system in pulmonary and renal vasculopathy: les liaisons dangereuses
Author(s) -
JeanLuc Vachiéry,
Anthony P. Davenport
Publication year - 2009
Publication title -
european respiratory review
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.565
H-Index - 66
eISSN - 1600-0617
pISSN - 0905-9180
DOI - 10.1183/09059180.00005709
Subject(s) - medicine , endothelin receptor , endothelin 1 , lung , receptor , kidney , vascular tone , endothelins , pathological , pharmacology , vasodilation
Endothelial cells regulate vascular tone largely by the actions of endothelin-1. Endothelin-1 is a potent vasoconstrictor, with effects that are dependent on the receptors to which it binds as well as their location. Endothelin-1 dysregulation is implicated in pathological conditions, including those of the pulmonary vasculature and the kidney. In this review, we describe the physiology and actions of endothelin-1 in lung and renal tissues and discuss therapies that disrupt these interactions in disease states. We provide an overview of the current clinical progress of these targeted agents and provide perspectives on the treatment of pulmonary and renal diseases with endothelin receptor antagonists.