Antithrombotic effect of a monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor in an experimental animal model | Zendy

BS Coller | Zendy; JD Folts | Zendy; LE Scudder | Zendy; Steven R. Smith | Zendy

Open Access

Antithrombotic effect of a monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor in an experimental animal model

Author(s) -

BS Coller,

JD Folts,

LE Scudder,

Steven R. Smith

Publication year - 1986

Publication title -

blood

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.515

H-Index - 465

eISSN - 1528-0020

pISSN - 0006-4971

DOI - 10.1182/blood.v68.3.783.783

Subject(s) - antithrombotic , platelet , monoclonal antibody , ex vivo , thrombus , platelet membrane glycoprotein , fibrinolytic agent , medicine , in vivo , pharmacology , platelet glycoprotein gpiib iiia complex , platelet activation , platelet aggregation inhibitor , antibody , immunology , chemistry , in vitro , biology , biochemistry , microbiology and biotechnology

A murine monoclonal antibody directed at the platelet glycoprotein IIb/IIIa complex, which blocks platelet aggregation ex vivo, was tested for its antithrombotic effects in an established animal model of acute platelet thrombus formation in partially stenosed arteries. Infusion of 0.7 to 0.8 mg/kg of the F(ab')2 fragment of the antibody completely blocked new thrombus formation despite multiple provocations, making it the most potent antithrombotic agent tested in this model.

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