STING and transplantation: can targeting this pathway improve outcomes? | Zendy

Cameron S. Bader | Zendy; Lei Jin | Zendy; Robert B. Levy | Zendy

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STING and transplantation: can targeting this pathway improve outcomes?

Author(s) -

Cameron S. Bader,

Lei Jin,

Robert B. Levy

Publication year - 2021

Publication title -

blood

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.515

H-Index - 465

eISSN - 1528-0020

pISSN - 0006-4971

DOI - 10.1182/blood.2020008911

Subject(s) - sting , hematopoietic stem cell transplantation , transplantation , immunology , medicine , hematopoietic cell , graft versus host disease , disease , haematopoiesis , stem cell , biology , genetics , engineering , aerospace engineering

Stimulator of interferon genes (STING) is an innate immune sensor of cytoplasmic dsDNA originating from microorganisms and host cells. STING plays an important role in the regulation of murine graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and may be similarly activated during other transplantation modalities. In this review, we discuss STING in allo-HSCT and its prospective involvement in autologous HSCT (auto-HSCT) and solid organ transplantation (SOT), highlighting its unique role in nonhematopoietic, hematopoietic, and malignant cell types.

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