ALKYLATION OF AMINES: A STUDY OF METHYLATION AND ITS EFFECTS ON AMINES | Zendy

Jacob Y. Terner | Zendy; George Clark | Zendy

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ALKYLATION OF AMINES: A STUDY OF METHYLATION AND ITS EFFECTS ON AMINES

Author(s) -

Jacob Y. Terner,

George Clark

Publication year - 1960

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/8.3.184

Subject(s) - methylation , alkylation , chemistry , nitrous acid , methanol , alcohol , organic chemistry , chloride , salt (chemistry) , oxidative phosphorylation , biochemistry , medicinal chemistry , catalysis , gene

The effect of normal methylation procedures upon tissue was reexamined. It was demonstrated that the methyl alcohol and HCl prevent the oxidative destruction of amines by either chloramine T or nitrous acid while effecting in no way their salt forming properties. It was shown that the ethyl chloride in methanol will give much the same effect. The authors conclude that methylation at higher temperatures alkylates amines.

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