Human autoantibodies to spermatogenic antigens and Sertoli cells. | Zendy

Thomas Haaf | Zendy; A G Groscurth | Zendy; Andreas Machens | Zendy; Michael Schmid | Zendy

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Human autoantibodies to spermatogenic antigens and Sertoli cells.

Author(s) -

Thomas Haaf,

A G Groscurth,

Andreas Machens,

Michael Schmid

Publication year - 1990

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/38.1.2403577

Subject(s) - autoantibody , sertoli cell , seminiferous tubule , antigen , biology , spermatogenesis , meiosis , acrosome , immunofluorescence , immunology , staining , microbiology and biotechnology , antibody , sperm , endocrinology , genetics , gene

Immunofluorescence staining using human autoantibodies is a simple and reliable method for investigation of meiotic and post-meiotic cells. Patients suffering from autoimmune diseases often produce circulating autoantibodies to antigens of germ cells and Sertoli cells. Four hundred human autoimmune sera were screened by indirect immunofluorescence on mouse seminiferous tubule cells. Autoantibodies of several specificities were found: one group reacted with organelles of meiotic prophase spermatocytes or spermatozoa. Included in this group were autoantibodies to synaptonemal complexes, sex vesicle, acrosome, and sperm tail. A second group of autoantibodies was found to stain different spermatogenic cell types uniformly, such as round spermatids or Sertoli cells.

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