Immunohistochemical localization of relaxin in human prostate. | Zendy

Sokol R Z | Zendy; Wang X S | Zendy; Lechago J | Zendy; Johnston P D | Zendy; Swerdloff R S | Zendy

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Immunohistochemical localization of relaxin in human prostate.

Author(s) -

Sokol R Z,

Wang X S,

Lechago J,

Johnston P D,

Swerdloff R S

Publication year - 1989

Publication title -

the journal of histochemistry and cytochemistry : official journal of the histochemistry society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/37.8.2666509

Subject(s) - relaxin , immunostaining , immunoperoxidase , antibody , polyclonal antibodies , immunohistochemistry , biology , prostate , microbiology and biotechnology , primary and secondary antibodies , endocrinology , medicine , chemistry , immunology , monoclonal antibody , hormone , cancer

We identified relaxin in human male prostate by use of an anti-human relaxin analogue polyclonal antibody and the avidin-biotin-immunoperoxidase method. The antibody was obtained by immunizing a rabbit with a synthetic human relaxin analogue which has 95% sequence homology with native human relaxin. Human prostate tissues incubated with the anti-human relaxin analogue exhibited positive immunostaining up to an antibody dilution of 1:3200. Inhibition of immunostaining with this antibody by excess relaxin analogue demonstrated specificity of the antibody. The exact role of relaxin in human male reproductive physiology remains to be fully elucidated.

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