Immunohistochemical localization of atrial natriuretic peptide receptor in bovine kidney and lung. | Zendy

Satoshi Kawaguchi | Zendy; Keiko Uchida | Zendy; Takahiro Ito | Zendy; Masamichi Kozuka | Zendy; Motoyuki Shimonaka | Zendy; Takeshi Mizuno | Zendy; Shigehisa Hirose | Zendy

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Immunohistochemical localization of atrial natriuretic peptide receptor in bovine kidney and lung.

Author(s) -

Satoshi Kawaguchi,

Keiko Uchida,

Takahiro Ito,

Masamichi Kozuka,

Motoyuki Shimonaka,

Takeshi Mizuno,

Shigehisa Hirose

Publication year - 1989

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/37.11.2553804

Subject(s) - immunoperoxidase , antiserum , atrial natriuretic peptide , receptor , kidney , lung , immunofluorescence , immunohistochemistry , endocrinology , medicine , chemistry , biology , microbiology and biotechnology , antibody , pathology , monoclonal antibody , immunology

Receptors for atrial natriuretic peptide (ANP) were localized in the alveoli and bronchiolar smooth muscle cells of bovine lung and in podocytes of the kidney by immunofluorescence and immunoperoxidase methods. Two specific antisera were raised against the ANP receptor purified from bovine lung plasma membranes: anti-Rc 140 and anti-Rc 70. Anti-Rc 140 was raised against the 140 KD native receptor having a homodimeric structure, and anti-Rc 70 was elicited by immunizing a rabbit with the 70 KD reduced subunits. Essentially identical staining patterns were obtained with both antisera. Identification of ANP receptor sites would provide useful information in understanding the pulmonary and renal actions of ANP.

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