Localization of glycoproteins in insulin secretory granules by ultrastructural autoradiography. | Zendy

Antônio Haddad | Zendy; Beatrix Markus Kopriwa | Zendy; Geneviève Pelletier | Zendy

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Localization of glycoproteins in insulin secretory granules by ultrastructural autoradiography.

Author(s) -

Antônio Haddad,

Beatrix Markus Kopriwa,

Geneviève Pelletier

Publication year - 1987

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/35.10.3305700

Subject(s) - glycoprotein , granule (geology) , fucose , insulin , ultrastructure , pancreatic islets , chemistry , biochemistry , secretory protein , islet , secretion , microbiology and biotechnology , biology , endocrinology , anatomy , paleontology

To determine whether or not the secretory granules of insulin-secreting cells contained glycoproteins, isolated rat pancreatic islets were incubated for 2 and 4 hr in a medium containing L-[3H]-fucose. Quantitative analysis of high-resolution electron microscopic autoradiographs of the insulin-secreting beta cells demonstrated that glycoproteins with fucose residues are contained within the insulin secretory granule.

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