Marginal zone macrophages in the mouse spleen identified by a monoclonal antibody. Anatomical correlation with a B cell subpopulation. | Zendy

E Van Vliet | Zendy; Marleen Melis | Zendy; Willem van Ewijk | Zendy

Open Access

Marginal zone macrophages in the mouse spleen identified by a monoclonal antibody. Anatomical correlation with a B cell subpopulation.

Author(s) -

E Van Vliet,

Marleen Melis,

Willem van Ewijk

Publication year - 1985

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/33.1.3880783

Subject(s) - marginal zone , spleen , red pulp , monoclonal antibody , antibody , biology , antigen , immune system , stromal cell , population , macrophage , immunology , immunoglobulin m , peripheral blood mononuclear cell , microbiology and biotechnology , b cell , immunoglobulin g , medicine , in vitro , cancer research , biochemistry , environmental health

The reactivity of a monoclonal antibody, ER-TR9, that demonstrates heterogeneity among mononuclear phagocytes is described. In the spleen, ER-TR9 exclusively reacts with a population of macrophages located in the marginal zone. ER-TR9 does not react with macrophage antigen 1-positive red pulp macrophages or any other types of splenic stromal cells. ER-TR9+ ve cells localize in anatomical proximity of a subpopulation of B cells, i.e., B cells that are immunoglobulin M positive and weakly positive to negative for immunoglobulin D. The possible significance of this particular interaction between both cell types during the immune response is discussed.

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