A double fluorescence method for determining doxorubicin distribution and vascular supply in the mouse kidney. | Zendy

Nicolas Paschoud | Zendy; Colin R. Bignell | Zendy; H Reinhold | Zendy

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A double fluorescence method for determining doxorubicin distribution and vascular supply in the mouse kidney.

Author(s) -

Nicolas Paschoud,

Colin R. Bignell,

H Reinhold

Publication year - 1985

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/33.1.2578145

Subject(s) - doxorubicin , dextran , fluorescence , conjugate , distribution (mathematics) , kidney , chemistry , in vivo , fluorescence microscope , blood supply , biophysics , pathology , biology , medicine , chromatography , chemotherapy , surgery , endocrinology , optics , mathematical analysis , physics , mathematics , microbiology and biotechnology

Freeze-sectioning followed by freeze-drying completely preserves the topographic distribution of soluble substances, with the additional advantage of permitting permanent mounting. This rapid and effective technique was applied to study the distribution of fluorescence of the cytotoxic drug Doxorubicin in microscopic slices from in vivo treated animals. A fluorescent conjugate of different fluorescence, Blankophor-G-Dextran, which remained in the vessels, was used in the same living animals to characterize the vascular supply in the kidney of treated mice in relation to Doxorubicin distribution.

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