A monoclonal antibody detecting neural and neuroendocrine differentiation. | Zendy

A P Sappino | Zendy; R. A. Jeffrey McIlhinney | Zendy; M. Ellison | Zendy; Padraic Monaghan | Zendy; Alan Nevill | Zendy

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A monoclonal antibody detecting neural and neuroendocrine differentiation.

Author(s) -

A P Sappino,

R. A. Jeffrey McIlhinney,

M. Ellison,

Padraic Monaghan,

Alan Nevill

Publication year - 1984

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/32.10.6384361

Subject(s) - immunocytochemistry , monoclonal antibody , enolase , enterochromaffin cell , antibody , immunohistochemistry , pathology , biology , microbiology and biotechnology , neuroendocrine differentiation , epitope , immunology , medicine , biochemistry , receptor , cancer , genetics , prostate cancer , serotonin

A monoclonal antibody, named LICR-LON-E36, has been produced to the acidic fraction of soluble protein extracts of human brains. Using immunocytochemistry, it stained normal peripheral nerves, adrenal medulla, pancreatic islets, and enterochromaffin cells, in addition to recognizing an intracytoplasmic epitope in phaeochromocytomas, carcinoid tumors, some small-cell anaplastic lung, and a few breast carcinomas. Microenzyme-linked immunosorbent assay and electrophoretic nitrocellulose blotting experiments confirmed that the antibody is not directed at neuron-specific enolase. Its potential use as an immunological probe for neural and neuroendocrine differentiation is discussed.

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