Monoclonal antibody LICR-LON-E36 recognizes gonadotrophs in female rat pituitaries. | Zendy

Padraic Monaghan | Zendy; A P Sappino | Zendy; J. David B. Roberts | Zendy; Melanie A. Knight | Zendy; Jayne E. Ellis | Zendy; Takashi Nakajima | Zendy

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Monoclonal antibody LICR-LON-E36 recognizes gonadotrophs in female rat pituitaries.

Author(s) -

Padraic Monaghan,

A P Sappino,

J. David B. Roberts,

Melanie A. Knight,

Jayne E. Ellis,

Takashi Nakajima

Publication year - 1984

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/32.10.6090532

Subject(s) - immunogold labelling , immunoperoxidase , gonadotropic cell , luteinizing hormone , endocrinology , monoclonal antibody , medicine , antibody , immunocytochemistry , biology , hormone , follicle stimulating hormone , microbiology and biotechnology , immunology

The distribution of the antigen localized by monoclonal antibody LICR-LON-E36 has been studied by means of light and electron microscopical immunocytochemical procedures on resin-embedded pituitaries from male and female rats. Using both immunoperoxidase and immunogold labeling techniques, the localization of LICR-LON-E36 has been compared with that obtained with antibodies against the beta subunit of rat luteinizing hormone (beta LH) and human follicle stimulating hormone (beta FSH), porcine adrenocroticotropic hormone (ACTH) and rat S-100. LICR-LON-E36 is localized in a portion of beta LH-containing cells in female rat pituitaries and where present both antigens are localized within the same storage granules. LICR-LON-E36 is rarely detectable within beta LH-containing cells of male rat pituitaries that also stain positively with anti-beta FSH antibodies. ACTH and S-100 were localized within different cell populations.

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