New fluorochromes for thiols: maleimide and iodoacetamide derivatives of a 3-phenylcoumarin fluorophore. | Zendy

Theodore O. Sippel | Zendy

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New fluorochromes for thiols: maleimide and iodoacetamide derivatives of a 3-phenylcoumarin fluorophore.

Author(s) -

Theodore O. Sippel

Publication year - 1981

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/29.2.7019305

Subject(s) - iodoacetamide , maleimide , chemistry , fluorophore , adduct , selectivity , reactivity (psychology) , fluorescence , thiol , photochemistry , cysteine , polymer chemistry , organic chemistry , catalysis , enzyme , medicine , physics , alternative medicine , pathology , quantum mechanics

N-(4-(7 - Diethylamino - methylcoumarin - 3 yl)phenyl)maleimide (CPM) and the corresponding iodoacetamide are described. When applied to sections at pH 6 and 9, respectively, the two fluorogens are very similar in their reactivity and selectivity toward thiols with which they form adducts having much the same bright blue fluorescence. However, difference in other properties favor CPM for further study.

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