Influence of two different fixatives on the identification of plasma cells in human rectal mucosa. | Zendy

Martin F. Heyworth | Zendy

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Influence of two different fixatives on the identification of plasma cells in human rectal mucosa.

Author(s) -

Martin F. Heyworth

Publication year - 1980

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/28.9.6157713

Subject(s) - immunoperoxidase , fixative , pathology , fixation (population genetics) , staining , chemistry , antibody , saline , biology , immunology , medicine , biochemistry , monoclonal antibody , endocrinology , gene

Plasma cells in sections of bisected human rectal biopsy specimens, fixed in two alternative fixatives, were enumerated after staining by an indirect immunoperoxidase procedure intended to demonstrate immunoglobulin-containing cells. The counts of immunoperoxidase-positive plasma cells were significantly higher after fixation in formol sublimate than after fixation in formol saline. Formol sublimate appears to be a more reliable fixative than formol saline for specimens of rectal mucosa in which quantitation of plasma cells, stained for intracellular immunoglobulin by an immunoperoxidase technique, is intended.

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