Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts. | Zendy

M C Willingham | Zendy; Frederick R. Maxfield | Zendy; Ira Pastan | Zendy

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Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts.

Author(s) -

M C Willingham,

Frederick R. Maxfield,

Ira Pastan

Publication year - 1980

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/28.8.6160180

Subject(s) - endocytosis , golgi apparatus , microbiology and biotechnology , endoplasmic reticulum , vesicle , cytoplasm , lysosome , receptor mediated endocytosis , receptor , alpha 2 macroglobulin , endosome , ligand (biochemistry) , chemistry , cell , biology , biochemistry , macroglobulin , membrane , enzyme

Alpha 2-macroglobulin is internalized into cultured fibroblasts by receptor-mediated endocytosis. This ligand binds initially to diffusely distributed receptors on the cell surface which cluster rapidly into bristle-coated pits. Within a few minutes at 37 degrees C, these complexes are internalized into uncoated cytoplasmic vesicles, called receptosomes, which move about in the cell by saltatory motion. These vesicles interact with the Golgi-endoplasmic reticulum-lysosome system in the cell to deliver the ligand to newly formed lysosomes within 30--60 min.

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