Estrogen receptor cytochemistry by fluorescent estrogen. | Zendy

I Nenci | Zendy; Walter B. Dandliker | Zendy; C.Y. Meyers | Zendy; Elisabetta Marchetti | Zendy; Andrea Marzola | Zendy; Guidalberto Fabris | Zendy

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Estrogen receptor cytochemistry by fluorescent estrogen.

Author(s) -

I Nenci,

Walter B. Dandliker,

C.Y. Meyers,

Elisabetta Marchetti,

Andrea Marzola,

Guidalberto Fabris

Publication year - 1980

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/28.10.7419900

Subject(s) - estrogen , estrogen receptor , estrogen receptor beta , estrone , receptor , chemistry , biology , microbiology and biotechnology , biochemistry , endocrinology , cancer , breast cancer , genetics

A recently synthesized fluorescein-labeled estrogen (17FE, 1-(N)-fluoresceinyl-estrone-thiosemicarbazone) interacts with estrogen-target cells like the native hormone and visualizes the uptake, transport, and distribution of estrogen in intact target cells. Moreover, estrogen binding sites are traced by 17FE in cryostat sections of estrogen target tissues as well. Cell and tissue 17FE binding sites fulfill the accepted criteria for specific estrogen receptors (finite binding capacity, high affinity, steroid and tissue specificity). This fluorescent probe allows estrogen receptors to be studied in a wide variety of cell and tissue preparations under varying conditions of physiologic and pathophysiologic interest.

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