Flow-system measurement of cell impedance properties. | Zendy

R. A. Hoffman | Zendy; W Britt | Zendy

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Flow-system measurement of cell impedance properties.

Author(s) -

R. A. Hoffman,

W Britt

Publication year - 1979

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/27.1.374580

Subject(s) - capacitance , body orifice , electrical impedance , materials science , electrical resistivity and conductivity , flow resistance , chinese hamster ovary cell , electrical resistance and conductance , flow (mathematics) , electrode , chemistry , electrical engineering , composite material , mechanics , physics , engineering , biology , anatomy , biochemistry , receptor

A flow-system technique has been developed that detects the high-frequency resistance and capacitance changes in a sensing orifice due to the passage of cells through the orifice. The resistance and capacitance changes are related to cell properties such as size, plasma membrane capacitance, and electrical resistivity of the cell interior. The relationship between measured impedances and cellular properties is discussed, and the prototype instrument for making such measurements is described. The instrument can simultaneously detect the dc Coulter volume and two ac parameters related to the complex ac impedance change. Some initial tests of the instrument using plastic microspheres and Chinese hamster ovary cells are described.

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