Immunoperoxidase localization of vitamin D dependent calcium binding protein. | Zendy

Robert L. Morrissey | Zendy; D. T. Zolock | Zendy; Thomas J. Bucci | Zendy; Daniel D. Bikle | Zendy

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Immunoperoxidase localization of vitamin D dependent calcium binding protein.

Author(s) -

Robert L. Morrissey,

D. T. Zolock,

Thomas J. Bucci,

Daniel D. Bikle

Publication year - 1978

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/26.8.357647

Subject(s) - calcium , extracellular , cytoplasm , calcium binding protein , cholecalciferol , chemistry , vitamin d and neurology , vitamin , immunoperoxidase , calcium in biology , intracellular , calcium metabolism , endocrinology , medicine , trpv6 , microbiology and biotechnology , antibody , biochemistry , biology , immunology , monoclonal antibody , organic chemistry

Calcium binding protein (CaBP) was localized by the indirect peroxidase-labeled antibody method in chick duodenum 72 hr after administering 32.5 nmol of cholecalciferol to vitamin D-deficient chicks. CaBP was observed in cytoplasm and nuclei of absorptive cells but was absent from goblet cells. Our results are consistent with the suggested functional role for CaBP in the prevention of intracellular accumulation of calcium by preventing mitochondrial accumulation of calcium, enhancing removal of calcium from absorptive cells, and/or preventing the "leaking" of calcium into cells through the lateral borders. They are not consistent with an extracellular functional role for CaBP.

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