Computer-assisted karyotyping with human interaction. | Zendy

A. Oosterlinck | Zendy; Johanna Van Den Daele | Zendy; Jessica de Boer | Zendy; F Dom | Zendy; A. Reynaerts | Zendy; Herman Van den Berghe | Zendy

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Computer-assisted karyotyping with human interaction.

Author(s) -

A. Oosterlinck,

Johanna Van Den Daele,

Jessica de Boer,

F Dom,

A. Reynaerts,

Herman Van den Berghe

Publication year - 1977

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/25.7.330726

Subject(s) - karyotype , computer science , classifier (uml) , chromosome analysis , technician , artificial intelligence , chromosome , computational biology , biology , genetics , engineering , electrical engineering , gene

A system for machine assisted karyotyping and chromosome analysis has been developed. The system uses a drum- or TV-scanner as input device, runs provisionally in 32 K memory, and also allows human interaction on several stages. The accuracy with which banded chromosomes are karyotyped depends strongly on the type of classifier and varies from 40 up to 80%. The accuracy of the human assisted classifier (98%) comes close to that of a skilled technician (99.5%) using manual chromosomal analysis. Due to technical and memory limitations, the time necessary for the karyotyping of one cell is too long and depends on the interaction time; however karyotyping within 5 min, including human interaction, will be possible in the near future.

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