The automated classification of mitotic phase for human chromosome spreads. | Zendy

Richard P. Bishop | Zendy; Ian Young | Zendy

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The automated classification of mitotic phase for human chromosome spreads.

Author(s) -

Richard P. Bishop,

Ian Young

Publication year - 1977

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/25.7.330725

Subject(s) - mitosis , chromosome , karyotype , histogram , computer science , word error rate , microscope , phase (matter) , process (computing) , artificial intelligence , optics , biology , genetics , physics , image (mathematics) , quantum mechanics , gene , operating system

A system has been developed that automatically recognizes the mitotic phase of human chromosome spreads for karyotyping. Suitable spreads are classified into one of five subphases of mitosis. Classification is performed on the basis of summed chromosome length and most probable chromosome width. Classification requires 100-500 msec. A television camera scans the spread through microscope optics; computer and special purpose electronics process the video signals to generate run length histograms. The histograms are used to determine mitotic phase. Unbanded spreads, 133, were classified with a 4.5% error rate. One hundred banded spreads were classified with a 15% error rate.

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